Why CKD affects sexual function
Multiple factors combine:
- Hormonal: low testosterone, raised prolactin, disturbed oestrogen cycles.
- Vascular: endothelial dysfunction reduces blood flow to genitals.
- Neurological: autonomic neuropathy from diabetes/uraemia.
- Medication side-effects: beta blockers, diuretics, some antidepressants.
- Psychological: depression, body image (catheters, fistulas, PD line).
Treatments for men
- PDE5 inhibitors (sildenafil, tadalafil): first line. Reduced doses in advanced CKD.
- Testosterone replacement if confirmed deficient (check trough morning level twice).
- Vacuum devices, intracavernosal injections, penile implants — second/third line.
- Treat depression and anaemia simultaneously — often improves libido alone.
Kidney Vitality is a daily multivitamin developed by a UK Consultant Nephrologist using renal nutrition principles. It contains no added potassium, magnesium, phosphorus or iron, and no herbal blends. See the formulation.
Treatments for women
- Vaginal moisturisers and lubricants for dryness — water-based for daily use, silicone-based for intercourse.
- Low-dose vaginal oestrogen is safe even after transplant (discuss with team).
- Pelvic floor physiotherapy for arousal and orgasm difficulty.
- Psychosexual counselling — often available through your renal unit or via Relate.
Contraception and fertility
- Avoid combined oral contraceptive pill if uncontrolled BP or proteinuria — use progestogen-only or copper coil.
- ACE inhibitors and ARBs are teratogenic — switch to labetalol/nifedipine before pregnancy.
- Mycophenolate (MMF) must be stopped 6 weeks before conception (both men and women).
- Tacrolimus, ciclosporin, azathioprine and prednisolone are pregnancy-compatible.
- Fertility usually returns within 3–6 months after kidney transplant.
Talking to your team
Most renal units in the UK now ask about sexual function as part of annual review. If yours doesn't, ask to be referred to a renal counsellor, urologist, gynaecologist or psychosexual therapist. Many issues are easily addressed — they are not 'just part of having kidney disease'.






