What stage 3 CKD means
Staging (KDIGO / NICE Ng203)
- Stage 1: eGFR ≥ 90 with kidney damage (e.g. raised ACR)
- Stage 2: eGFR 60–89 with kidney damage
- Stage 3a: eGFR 45–59
- Stage 3b: eGFR 30–44
- Stage 4: eGFR 15–29
- Stage 5: eGFR < 15 or on dialysis
CKD is also classified by urine albumin-to-creatinine ratio (ACR):
- A1: < 3 mg/mmol (normal/mild)
- A2: 3–30 mg/mmol (moderate)
- A3: > 30 mg/mmol (severe)
A person with eGFR 50 and ACR 40 has stage 3a A3 — higher risk than 3a A1 despite the same eGFR.
Common Causes
- Diabetes (commonest)
- High blood pressure
- Glomerular disease (e.g. IgA nephropathy)
- Polycystic kidney disease
- Recurrent infection or obstruction
Monitoring, diet and lifestyle
Monitoring (NICE Ng203)
- eGFR and urine ACR at least once a year
- More often (3–6 monthly) if eGFR falling, ACR > 30, or BP uncontrolled
- Check potassium, bicarbonate, calcium, phosphate, PTH, haemoglobin when indicated
- BP at every contact; home BP monitoring encouraged
DIET (UK renal dietitian guidance):
- Salt < 6 g/day; read labels for sodium
- Protein around 0.8 g/kg/day for most adults
- Plenty of veg and fruit — potassium restriction is rarely needed at stage 3 unless blood potassium is high
- Limit ultra-processed food (additive phosphate)
- 1.5–2 L fluid/day unless told otherwise
- Mediterranean or DASH pattern is well evidenced
Lifestyle
- Stop smoking
- Keep BMI in healthy range
- Avoid NSAIDs (ibuprofen, naproxen, diclofenac) unless your kidney team agrees
- Be cautious with herbal remedies and high-dose supplements
- Alcohol within UK low-risk limits (≤ 14 units/week)
Treatment that slows progression
Blood Pressure
- Target < 130/80 for most adults with CKD and raised ACR
- Home monitoring helps avoid white-coat readings
ACE INHIBITOR or ARB:
- First-line if ACR > 3 mg/mmol or you have diabetes with CKD
- Examples: ramipril, lisinopril, losartan, candesartan
- Recheck eGFR and potassium 1–2 weeks after starting or up-titrating
SGLT2 INHIBITOR (dapagliflozin or empagliflozin):
- NICE-recommended for CKD with ACR ≥ 22.6 mg/mmol, with or without diabetes
- Slows eGFR decline, reduces cardiovascular and kidney events
Diabetes & Cholesterol
- HbA1c target individualised
- Statin (usually atorvastatin 20 mg) for primary prevention in CKD
When To Refer To Nephrology
- eGFR < 30
- ACR > 70 mg/mmol
- Rapid decline (> 25% and stage change within 12 months, or > 15 mL/min/year)
- Uncontrolled BP on 4 drugs
- Suspected genetic kidney disease or rare cause






